The phosphate salt of codeine occurs as white, needle-shaped crystals or white crystalline powder. Codeine phosphate is freely soluble in water and a little soluble in Alcoholic beverages. The molecular excess weight is 406.37. Its molecular formulation is C18H21NO3•H3PO4 • ½ H2O, and it's got the following chemical construction.
Promethazine is really an H1 receptor blocking agent. In addition to its antihistaminic motion, it provides clinically valuable sedative and antiemetic effects. Promethazine is very well absorbed within the gastrointestinal tract. Medical effects are evident in just twenty minutes right after oral administration and usually previous four to six several hours, Even though They could persist providing twelve hrs.
Narcotics could develop adverse reactions which can obscure the scientific training course of sufferers with head accidents.
Pregnancy Tests: Diagnostic pregnancy exams according to immunological reactions among HCG and anti-HCG may well lead to Phony-adverse or Untrue-constructive interpretations.
If this SPL has inactivated NDCs stated because of the FDA initiated compliance action, They are going to be specified as such.
Since recurrences of NMS happen to be described with phenothiazines, the reintroduction of promethazine HCl need to be meticulously regarded.
Usual Grownup dosage is fifty mg Promethazine having an properly minimized dose of narcotic or barbiturate plus the necessary number of a belladonna alkaloid.
Small children Postmarketing cases of respiratory melancholy, like fatalities, are documented with use of promethazine in pediatric patients. Concomitant administration with other respiratory depressants may possibly increase the hazard of respiratory despair.
Promethazine is surely an H1 receptor blocking agent. Besides its antihistaminic action, it provides clinically practical sedative and antiemetic effects.
Promethazine HCl occurs as being a white to faint yellow, pretty much odorless, crystalline powder which slowly and gradually oxidizes and turns blue on prolonged publicity to air. It really is freely soluble in h2o and soluble in Liquor.
Postmarketing instances of respiratory melancholy, which includes fatalities, are actually described with utilization of promethazine hydrochloride in pediatric sufferers fewer than two years of age. A wide array of excess weight-centered doses of promethazine hydrochloride have resulted in respiratory melancholy in these clients.
Pediatric sufferers should be supervised to stop likely damage in bicycle Using or in other dangerous pursuits.
Stimulation could be obvious, especially in small children and geriatric people. Convulsions may well rarely arise. A paradoxical response has been reported in youngsters acquiring one doses of 75 mg to a hundred twenty five mg orally, characterized by hyperexcitability and nightmares.
Codeine Carcinogenicity research had been performed with codeine. Two-calendar year experiments in F344/N rats and B6C3F1 mice had been conducted to assess the carcinogenic potential click here of codeine. No evidence of tumorigenicity was observed in male and feminine rats at codeine dietary doses as many as 70 and 80 mg/kg/day (around such as fifteen and 20 moments, the MRHD with a mg/m2 basis, respectively).